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In this review, we emphasize on the current understanding of the inter-organ crosstalk between the liver and peripheral organs that participated in the pathogenesis of NAFLD (Fig. 1).
Dysfunction of adipose tissue in obesity, lipodystrophy or insulin resistance provides a source of excess fat and release of adipokines such as Leptin, Adiponectin, Resistin, and proinflammatory cytokines such as TNF-α and IL-6 that participated in the pathogenesis of NAFLD.
These data suggest that the PERK pathway is participated in the pathogenesis of aged related neurodegenerative diseases.
Whether HMGB1 participated in the pathogenesis of AAV, and then the underlying mechanism was not fully clear yet.
Accumulated studies indicate that bacteria or virus infections are participated in the pathogenesis of KD [ 8, 9].
It has been shown that TLR4 and its signal pathway participated in the pathogenesis of diabetes and diabetic nephropathy.
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Peritoneal fluid (PF) inflammatory factors may participate in the pathogenesis of endometriosis.
We therefore examined whether MCV might participate in the pathogenesis of prostate cancer.
Staphylococcus aureus enterotoxin B (SEB) might participate in the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP).
Recently, CxHCs have been associated to denervation-induced skeletal muscle atrophy (1), and may also participate in the pathogenesis of corticoids induced muscle atrophy.
This suggests that host-related factors, in addition to an inhaled antigen in cigarette smoke, participate in the pathogenesis of PLCH [5, 6].
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