STAT1 also participates in the differentiation of B cells [ 4, 5] and T cells [ 6, 7].
However, it is probable that some of these proteins participate in the differentiation of tracheary elements, such as AtXTH32 which was only identified at 11 days.
The periosteum, a fibrous tissue which covers the bone surface, is known to participate in the differentiation of chondrocytes and osteoblasts in fracture healing [ 25].
Multiple signaling pathways have been demonstrated to participate in the differentiation of an osteoblast progenitor to a committed osteoblast [ 30, 31].
Data show that plant bZIP proteins participate in the differentiation of many organs and tissues, embryogenesis, seed maturation, floral transition and initiation, and vascular development.
Because each of these NTFs participate in the differentiation of neural precursor cells into neurons, we examined their morphological changes after PC12 cells were cultured in BM supplemented with 50 ng/mL NGF, DPC-CM, and BM.
Considering Pdx-1 is required for β-cell generation and maturation at embryonic period, we further assume that Foxo1 probably participates in the differentiation of ES cells into functional INS+ cells.
Several observations on SoxB1 mouse mutants have indicated that these proteins might participate in the differentiation of select neuron subtypes (Ekonomou et al., 2005; Taranova et al., 2006; Cavallaro et al., 2008).
Extensive studies through knockout/knockdown or overexpression approaches in model plant species demonstrated that members of the bZIP TF family participate in the differentiation of many organs and tissues, embryogenesis, seed maturation, floral transition and initiation and vascular development in plants [ 8, 18, 19].
Our study provides proof that members of growth factors (BMP8A, TGFβ2, NFIB, FGF9 and FGF20), signaling pathways (MAPK6, MAPK10, MAPK14 and Notch2), G protein coupled receptor pathways (GPR110 and GPSM2) and transcription factors (Dlx5 and TFAP2A) participate in the differentiation of PABs to SABs.
