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KK participated in devising the clinical design of the study.
MJTR participated in devising the methodology and helped to draft the manuscript.
LFAW participated in devising the methodology and helped to draft the manuscript.
BM participated in devising the analytical plan, and edited the draft.
GEH participated in devising the analytical plan, carried our data analysis and drafted the manuscript.
MD significantly participated in devising the protocol of the study and in the analysis of data; he contributed to writing the manuscript and its revision.
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TJT and FM devised and participated in all aspects of the study.
MBD: Methyl-CpG-binding domain HDAC: histone deacetylase TCR: carried out the database searches, comparative analyses and molecular genetic experiments HHR: revised the manuscript and participated in the study coordination UAN: devised the study, supervised and coordinated it and drafted the manuscript All authors read and approved the manuscript.
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