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In the Civil Engineering strand, 9 countries participated comprising 92 universities and 6,078 students.
Most (52/60) NHS Trusts participated, comprising a total of 133 mental health inpatient rehabilitation units.
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Of the 8,559 patients recruited to the EPI3 cross-sectional study, 1,840 (21.5%) were adults consulting mainly for an MSD, of whom 1,143 (62.7%) patients recruited by 825 GPs across France consented to participate, comprising the EPI3-MSD study database.
Except for those transferred to another institution or who were on non-health leave (n = 155), all employees were invited to participate, comprising the eligible population for the study (n = 4,459 subjects).
Therefore, in order to realise the required sample size of 1500 patients, each of the random sample of 800 osteopaths was asked to invite 14 patients to participate, comprising at least 4 consecutive new patients and up to 10 consecutive returning patients.
The two schools that accepted to participate comprised of three separate school campuses.
The potential controls who declined to participate comprised 110 women (84%).
The three who did not participate comprised one who declined and two who were too acutely unwell to participate (table 1).
If invited subjects who did not want to participate comprised more tobacco smokers than those who actually participated, such non-random self-selection might have contributed to the observed positive dose-response association with tobacco consumption.
35 These concerns likely play a role in the relatively low trial participation rates and may reduce the ecological validity of trials if patients who consent to participate comprise a small and qualitatively different group than the overall patient population who will receive the intervention in practice.
A total of 1,137 unrelated participated subjects comprising 747 hypertensive patients (479 men and 268 women; mean age = 51.52; SD±9.46) and 390 normotensive control subjects (233 men and 157 women; mean age = 51.02; SD±7.66) were recruited for the present study.
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