Although organotypic models have fully differentiated keratinocytes, they also have limitations as wound healing is affected both by tissue architecture and the participating cell types [53].
Recently, some studies also showed that LncRNA participate cell cycle regulation through various routes [ 24– 26].
The participating cells contain information needed to develop everything "downstream," but can never become more proximal structures.
The differentiation of xylem culminates in the death of the participating cells, and the vessels are formed of chains of empty walls.
And for LC-RB, all the participating cells can work sequentially in order to complete the scheduling.
At each stage, the quality and utility of the information available to the participating cells is being assessed.
(2014) show that epithelial cell clusters secrete FGFs into a microlumen, restricting FGF localization so that participating cells coordinate differentiation and collective migration via luminal signaling.
Cell viability within the bio-engineered organ constructs is an essential parameter reflecting the performance of participating cells during long-term ex vivo culture, and is a prerequisite for further functional performance.
