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This suggests that the recA gene must participate in the repair of lesions other than strand breaks, whose formation is affected by the presence of oxygen (A46).
These enzymes participate in the repair of spontaneous protein damage by facilitating the conversion of L-isoaspartyl and D-aspartyl residues to normal L-aspartyl residues.
These enzymes can participate in the repair of damaged proteins by facilitating the conversion of abnormal L-isoaspartyl residues to normal L-aspartyl residues.
Considering the previously reported molecular functions of MutS, MutL, and MutS2, these proteins are expected to participate in the repair of oxidative DNA damage but not in detoxifying ROS.
Co-immunoprecipitation and pull-down experiments revealed previously-unknown interactions of MutS2 with MutS and MutL, indicating that these proteins cooperatively participate in the repair of oxidatively damaged DNA.
It is known that the DDB2 gene is expressed at a low baseline level in many human normal cells and is induced following UV irradiation to participate in the repair of DNA lesions [15], [23].
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These tumor suppressor genes normally function to maintain genome integrity by participating in the repair of DNA damage.
TDP1 is a gene that participates in the repair of Topo I DNA complexes.
PHGPx is the basis of a principal defense system that intimately participates in the repair of disrupted biomembranes [ 7].
Histone H2AX has been implicated in the maintenance of genomic stability by participating in the repair of DNA damage (Davalos and Campisi, 2003; Sengupta et al, 2004).
Interestingly, our previous study [ 24] showed that EPO therapy enhanced circulating numbers of EPCs [ 24], which, in turn, participated in the repair of cerebral vasculature.
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