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Data show that plant bZIP proteins participate in the differentiation of many organs and tissues, embryogenesis, seed maturation, floral transition and initiation, and vascular development.
However, it is probable that some of these proteins participate in the differentiation of tracheary elements, such as AtXTH32 which was only identified at 11 days.
The periosteum, a fibrous tissue which covers the bone surface, is known to participate in the differentiation of chondrocytes and osteoblasts in fracture healing [ 25].
Multiple signaling pathways have been demonstrated to participate in the differentiation of an osteoblast progenitor to a committed osteoblast [ 30, 31].
Because each of these NTFs participate in the differentiation of neural precursor cells into neurons, we examined their morphological changes after PC12 cells were cultured in BM supplemented with 50 ng/mL NGF, DPC-CM, and BM.
Several observations on SoxB1 mouse mutants have indicated that these proteins might participate in the differentiation of select neuron subtypes (Ekonomou et al., 2005; Taranova et al., 2006; Cavallaro et al., 2008).
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STAT1 also participates in the differentiation of B cells [ 4, 5] and T cells [ 6, 7].
Although p38, JUK and MEK/ERK signaling cascades participated in the differentiation of CML, only the MEK/ERK signal pathway has an essential role in MK differentiation.
Considering Pdx-1 is required for β-cell generation and maturation at embryonic period, we further assume that Foxo1 probably participates in the differentiation of ES cells into functional INS+ cells.
Recently, we have shown that apoptosis-associated factors, such as p53 and caspases participate in the differentiation process of mouse neural stem (NS) cells.
In addition, delta40-p53 appears to affect the Insulin Growth factor 1 receptor (IGF-1R) signaling, which has been shown to participate in the differentiation program of ES cells.
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