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Tachycardia could participate in the alteration of diastolic function by reducing diastolic filling time and/or decreasing coronary perfusion [28].
In N. vitripennis, venom lipases might participate in the alteration of host's lipid metabolism to the benefit of the developing parasitoid eggs [ 65] and a similar function is conceivable for C. inanitus.
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Because PIP2 is also involved in the mediation of gene expression and cell survival [51], [52], the present results suggest that METH preconditioning might have induced changes in lipid signaling, which might participate in the alterations of METH-induced transcriptional responses of the SN/VTA cell bodies.
This review will summarize and update the morphological and functional features of the endothelium and it will provide an overview of the major mechanisms participating in the alteration of endothelial functions at cardiovascular level in physiopathological states.
In addition to copy number alterations, genome-wide DNA methylation alterations may also participate in the development of UCs belonging to cluster B2.
Since polyamines are thought to play important roles in nucleic acid and protein synthesis during cellular maturation, these alterations may participate in the retardation of tissue growth seen in the perinatal opiate syndrome.
However, chromosome 18 is not predisposed to SI alteration and does not participate in the course of evolution.
We reasoned that a similar approach might help us to identify epigenetic alterations that participate in the acute effects of METH on gene expression in the rat dorsal striatum of METH-naïve and METH-pretreated rats.
Deletions and other alterations of the genes that participate in the regulation of Rb proteins, such as CDKN2A, CDK4 and CCND1, occur frequently in many tumours [ 6, 7].
Similar to the RAS alterations, BRAF mutations seem to poorly participate in the pathogenesis of human HCC.
Together with DNA sequence alterations, DNA aberrant cytosine methylation and microRNA deregulation, epigenetic modifications participate in the malignant transformation of cells.
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