Students on the Research Programmes have not obtained a higher degree, and can thus formally not participate in a PhD-programme, something which is presupposed by the scheme.
CAs participate in a variety of physiological processes including pH regulation, CO2 and HCO3- transport, ion transport, water and electrolyte balance, ureagenesis, gluconeogenesis and lipogenesis (reviewed in [ 5, 18]).
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This residue in HsAQP3 has been proposed to participate in the pH regulation of water permeability [ 49].
CA XIV, as a membrane-bound isozyme with its active site on the cell exterior, is a good candidate to participate in regulation of pH homeostasis and ion transport between the hepatocytes, bile canaliculi and hepatic sinusoids.
Histidine seemed to be best suited to participate in pH perception by ArsS, since according to its side chain pKa (6.1) free histidine residues will be protonated when the pH drops below 6, while the side chains of arginine (pKa = 12,5) and lysine (pKa = 10.8) are already protonated at neutral pH.
Other essential mechanisms for the colonisation of the gastric mucosa participate in pH homeostasis [ 18]: H. bizzozeronii CIII-1 contains the periplasmic α-carbonic anhydrase orthologue HBZC1_14670, which contributes to the urease-dependent response to acidity in H. pylori [ 19], but lacks an orthologue for the β-carbonic anhydrase.
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Here both isozymes may participate in ion transport and pH homeostasis across the plasma face of the sinusoidal endothelial cells.
Liu et al. [ 32] found glutamate decarboxylase is an enzyme catalyzing the conversion of L-glutamate to γ-aminobutyric acid, and suggested that it is possible that glutamate decarboxylase (gi|70609690) could participate in regulating the cytosolic pH.
The carbonic anhydrases (CAs) are zinc-containing metalloenzymes that catalyse the reversible hydration of carbon dioxide (CO2 + H2O ⇔ HCO3- + H+), and, thus, participate in the maintenance of pH homeostasis in the body [ 11- 14].
