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MicroRNAs - small, non-protein-coding RNAs that bind to and regulate mRNAs - also appear to be important participants in the regulation of DNA repair in response to chronic hypoxia [ 81].
Several of the other differentially expressed genes within the reactive stroma, annotated to the term extracellular region, were also candidate participants in the regulation of tumor growth and invasion.
They are also key participants in the regulation of cell death.
It is now becoming clear that EC may be viewed as active participants in the regulation of inflammation and leukocyte behavior.
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Using the Drosophila eye as a model system, Chen et al. described Atg7 as a downstream effector of heat shock protein 27, and as a participant in the regulation of normal eye development, neuronal homeostasis, and lifespan (Chen et al., 2012).
In conclusion, these data show that miR-200b/c is an important participant in the regulation of the migration and invasion potentials of cholangiocarcinoma cells.
Its development was motivated by the recognition of ERRα as a key participant in the regulation of cell differentiation, energy homeostasis, and metabolic syndromes.
There have been hints that the AHR may be a participant in the regulation of fat metabolism and obesity (Arsenescu et al. 2008; Kerley-Hamilton et al. 2012).
Lipids are recognized as key participants in the regulation and control of cellular function, having important roles in signal transduction processes.
Since TIMAP is involved in the regulation of EC barrier function [ 4], RACK1 should also be regarded as a participant in maintaining barrier integrity, through the regulation of TIMAP prenylation.
He called for a significant overhaul in the regulation of the financial industry, declaring that the current system of supervision was "confusing" and generated "perverse" incentives for financial participants.
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