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For each participant, trials with a wrong response and/or with reaction times beyond 2.5 standard deviations from the mean were marked as missing (8.4% of the observations).
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Group allocation is revealed to the participant, trial manager and trial therapists.
To date there have been several large (at least 7000 participants) trials testing the efficacy of antioxidant supplements in preventing cancer.
Of the 185 randomised clinical trials, 38 were parallel group (n=5111 participants) and 147 were crossover (n=7134 participants) trials, with a total of 12 245 participants.
The difference in reduction between treated patients and those given placebos was not statistically significant, however, though some researchers said that could have been because the 180-participant trial was too small.
Data from 138 CALORIES participants' trial records at UCLH were collected.
The 25-participant trial was evaluator-blinded, X-ray based and used the standard Cobb method for measuring results.
We examined participants' trial-by-trial adjustments in choice preferences during the initial learning task.
23 Interview transcripts will be anonymised using the participants' trial ID.
Table 1 summarizes the studies on design, number of participants, trial duration and data collection.
Important protocol modifications will be announced to relevant parties (eg, investigators, IRB, trial participants, trial registries and sponsor).
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CEO of Professional Science Editing for Scientists @ prosciediting.com