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In line with these heterochromatic, and thus gene-silencing properties, reporter genes inserted on the fourth chromosome often show a partially silenced, variegated expression (Wallrath and Elgin 1995; Wallrath et al. 1996; Sun et al. 2000).
This has partially silenced the critics who claim he became the richest man in the world because Bill Gates and Warren Buffett had given so much of their money away.
PTB was partially silenced in HeLa cells by using increasing concentration of siPTB.
Increases would have been most obvious in the partially silenced lines 60 and 37. Decreases would have been most obvious in the strongly silenced lines 231 and 308.
To further consolidate the observation, S10 extract isolated from HeLa cells, partially silenced for PTB expression was used for binding using Wt IRF2 probe.
Previous research has shown that plants with a partially silenced AtTOR gene show reduced growth (e.g. shorter root and shoot length, smaller rosette leaves) [40], [41].
Similar(30)
It provides a feasible method for either silencing an individual gene or simultaneously silencing or partially silencing a multi-gene family while at the same time minimizing the risk of unpredicted off-target effects [ 18].
And with a 7-4 record, Sarkisian needs a victory to move off the seven-win plateau and at least partially silence his critics heading into a bowl game.
Depending on the insertion site, flanking DNA regions may partially silence the inserted promoter.
Given that partially condensed silenced chromatin has a tendency to localize at the nuclear periphery (Shevelyov and Nurminsky, 2012), an ATR response regulating chromatin-lamin association in response to membrane stress might have important epigenetic implications.
An interesting result shown here is the capacity to partially reactivate silenced stable cell lines at early culture times, and the incapacity to achieve reactivation at later time points.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com