Bistable states correspond to a situation in which the two molecules oscillate between a "totally paired state" and a "partially paired state" (Fig. 6a), b) and c)).
Through immunolocalization, it was observed, in zygotene, 500 RAD51 signals per nucleus, clearly associated with the partially paired and paired chromosomes, which is consistent with its role in the homology search.
Two independent sets, consisting of 38 and 16 stomach cancer samples and 31 and 13 cancer-adjacent control samples from the same patients [44], [45] was used to assess the generality of the predicted markers, of which 12 are early stage samples partially paired with 10 control samples.
In contrast, 100% (n > 100 nuclei) of stage 10 nurse cell nuclei from Mrg15 RNAi-expressing tissue had partially paired or completely paired polytene chromosomes.
Then, each pair of the remained features was compared and the difference significance among these feature classifying performances was determined by the partially paired model [ 29, 30].
ROC curves and according discriminative properties for (partially) paired data should be statistically combined and plotted resulting in a combined AUC with corresponding confidence interval (ref vergara 2008, Metz 1998).
