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Previous work has identified Nav1.7 as a key player in pain signalling, and researchers have identified a number of rare mutations in the gene encoding it, which make people either completely or partially insensitive to pain.
We show that such convergence is partially insensitive to the order of summation of the expansion.
Regarding ethylene, the quadruple mutant is partially insensitive to ethylene and thus cannot be rescued by the hormone.
Other factors may also participate in the initial coupling of the clock to Fe responses, as hmr mutants are only partially insensitive to various Fe supply.
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These nociceptive tests are intact in TRPV1−/− mice and sensitive to acetaminophen, but considered to be partially or completely insensitive to COX inhibitors [3], [6], [8], [9], [24], [25].
Mitochondrial fractions isolated from tumours induced with the respiratory inhibitor rotenone lack respiratory control, oxidative phosphorylation, are partially or totally insensitive to cyanide and have a near-normal content of respiratory carriers.
The presence of oligomycin-insensitive, partially assembled ATP synthase complexes in Lrpprc knockout heart mitochondria prompted us to further investigate the bioenergetic properties.
We suggest that pragmatic problems associated with autistic spectrum disorder, to which standardised tests are largely insensitive, may partially explain this discrepancy.
Specifically, (i) nicotine-induced [H]-ACh release was TTX-insensitive but required extracellular calcium; (ii) the response to our standard pulse protocol was small (AUC: 0.15 with 100 pulses; 1.3 with 1000 pulses; Figure 7B); and (iii) increasing extracellular KCl from 4.8 to 25 mM increased [H]-ACh release in a partially calcium-dependent, TTX-insensitive manner.
Introduction of the ethylene-insensitive ein2 mutation partially rescues defective cell division, localization of PIN proteins, and vascular strand development.
"To me, it was partially, 'How do we ridicule this insensitive, callous statement?'".
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com