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One can only hope that the issues raised – namely what is actually the minimum effective dose, how best to administer possibly partially efficacious doses to reduce the burden of disease, and how to improve vaccine yield – will better prepare us in our ongoing battle with this very old enemy.
Commercial vaccines are only partially efficacious under field conditions.
The xanthine 7-riboside DBXRM, a full agonist, was only partially efficacious in β-arrestin translocation.
This combination may only be suitable to test drug candidates for side effect profiles at partially efficacious levels but not the maximum efficacious levels.
This challenge can be met by appropriate clinical trial design for partially efficacious vaccines and by analysis of natural infection cohorts.
This preventive policy seems partially efficacious on early manifestations of allergy but does not restrain the allergic march, especially in its respiratory manifestations.
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Human clinical trials of HSV-2 vaccines that elicit neutralizing antibodies have proven to be only partially effective suggesting that induction of effective T cell responses to HSV-2 is also a critical component to an efficacious vaccine.
These may, if found safe and efficacious, at least partially replace "specific" intravenous immunoglobulin (IVIG), which is IgG purified from individuals who have been vaccinated or from convalescing patients who have produced IgGs against a specific target (Llewelyn et al., 1992; Mire et al., 2016).
In addition to sorafenib, OGX-011 was also shown to exert an antiangiogenic activity in vivo (Jackson et al, 2005); therefore, this favourable growth inhibitory effect of combined OGX-011 and sorafenib therapy on in vivo ACHN tumours could partially be explained by the efficacious inhibition of angiogenesis by these two agents.
We showed that PE is efficacious against GBM cells and this effect can be partially reverted by iron chelators.
49 If in the first 15 days of treatment, medications and psychotherapy are not efficacious, treatment of sleep cycles, administered all night or partially (ie, second half of the night) produces stunning effects in just a few hours in 60% of the patients with major depression.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com