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We found that normal erythrocytes contained 240,000 copies of spectrin heterodimer, whereas erythrocytes from 14 patients with a variety of types of HS were all partially deficient in spectrin (range 74,000-200,000 copies), the magnitude of the deficiency correlating with the severity of the disease.
(1) A polA1 strain, deficient in DNA polymerase I, is partially deficient in nucleotide excision repair after UV irradiation.
Defects very evocative of FSHD have been observed in mouse model partially deficient for FAT1.
Here, we track the evolution of pellicle biofilms formed through genetic division of labour and ask whether partially deficient partners can evolve autonomy.
First, the cell must be proficient in nucleotide excision repair and, second, it must be at least partially deficient in postreplication repair.
Kline, D. D., Peng, Y. J., Manalo, D. J., Semenza, G. L. & Prabhakar, N. R. Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1 alpha.
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In addition, we find casp2 activity to be increased prior to other caspases in MnSOD-partially-deficient mice that have enhanced mitochondrial oxidant stress (data not shown).
From the bloodstream, the recombinant LSD enzyme can travel to affected tissues throughout the body, enter enzyme-deficient cells, and partially restore deficient lysosomal enzymatic functions.
It was concluded that damage during submergence is not associated with extensive anoxia, but that injury is linked to membrane peroxidation in seedlings that are partially oxygen deficient while submerged.
While we did not directly compare our technique with reconstruction techniques applied for complete ACL tears, the outcomes validated the results of previous studies noting that ACL augmentation could restore nearly normal anterior translation laxity of a partially ACL-deficient knee [7, 8, 9, 15, 35, 36, 37].
BECN1 is essential for autophagosome formation and, when ectopically expressed in partially autophagy-deficient human MCF7 breast cancer cells, it restores functional autophagy and suppresses tumorigenesis.
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