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Examination of integrin α2 knockout mice showed a multifaceted phenotype including defects of branching morphogenesis, hemostasis and a partially defective platelet interaction with collagen [ 7, 21].
In addition to defects in germline development, glp-4 (bn2 ts ) is also partially defective in somatic function.
Notably, the double mutant accumulated a considerable quantity of meiosis-specific transcripts at the permissive temperature 25°C, implying that the rrp6-ts32 and the pla1-ts37 alleles were both partially defective at this temperature, although each single mutant showed no obvious growth defect.
Holtkotter, O. et al. Integrin α 2-deficient mice develop normally, are fertile, but display partially defective platelet interaction with collagen.
Targeting Sirtase to a partially defective E silencer of the budding yeast mating type locus restores silencing, indicating that lysine acetylation turnover stabilizes heterochromatin in yeast.
Subsequent work showed that a strain with a partially defective telomerase, resulting in stably short telomeres but no senescence, had a severe growth disadvantage relative to a telomerase-proficient strain, as assessed by liquid competition experiments (Morris and Lundblad, 1997).
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Introduction of the ethylene-insensitive ein2 mutation partially rescues defective cell division, localization of PIN proteins, and vascular strand development.
Finally, reintroducing PPARγ into null TS cells, using an adenovirus, normalized invasion and partially reversed defective labyrinthine differentiation, as assessed both by morphology and marker analysis.
Interestingly, it was a genetic screen for a suppressor of the female sterile and partially phosphorylation defective BicDA40V mutant that lead to the isolation of the Su 66) mutant that revealed the only identifiable function of BicD phosphorylation.
The 5A3 deletion partially rescues defective repopulation in Gata2 mutant mice.
Constitutive activated β-catenin in Shh null background can partially rescue defective development of the GT and the cm.
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