Exact(13)
First generation HDACi are not selective except for a partial selectivity achieved 31, 32 in rare cases using bulk chemical groups to generate specific interactions with the external surface of the active site of the enzyme, like in tubacin.
The former responded well to sodium ions and the latter to nickel ions, thus partial selectivity for these ions is shown.
This device combines the great sensitivity and the partial selectivity toward oxidizing gases of a molecular organic semiconductor, copper phthalocyanine, with the O3 filtering capability of different carbonaceous nanomaterials located upstream the sensitive layer in the gas flux.
Although these difficulties can be colloquially interpreted as a deficiency in selectivity, the reality is that there is a surprising lack of consensus around a quantitative definition of selectivity for multivariate analytical measurements, and little discussion about the analytical implications of partial selectivity, which is a salient feature of most sensor arrays.
Partial selectivity was also observed at the feeding station scale (Table 2).
The partial selectivity for antagonizing pathologically activated NMDA receptors makes this drug a therapeutic candidate for many neurodegenerative/neuropsychiatric diseases.
Similar(47)
The partial substrate selectivity of the 120 kDa and low MW serine proteinases contained in TES deserves future studies.
The degrading activity of these enzymes on representative blood (albumin and IgG) and extracellular matrix (fibronectin and laminin) components not only extends previous observations using elastin and collagen [ 26] but also reveals the partial substrate selectivity of the 120 kDa complex and the low-MW proteinases in TES.
L-arginine analogs function as nonspecific NOS inhibitors; guanidine (aminoguanidine), isothiourea (aminoethyl-isothiourea), acetamide (N- [3- aminomethyl) benzyl]acetamide.2HCl, or 1400 W), and lysine (L-N6-[3- aminomethylysine, or L-NIL) derivatives have partial iNOS inhibenzyl]acetamidety; and nitroinadozole has partial nNOS selectivity.2HCl
Patch size and distance between patches did not affect either partial or cumulative selectivity.
Partial or cumulative selectivity indexes with different superscript are significantly different according to Duncan test.
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