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In the largest cases series published so far [ 23, 24], the combined use of thiosulphate and cinacalcet associated with complete regression of skin lesions in six of seven cases in the series of Canadian patients by Baldwin et al. [ 23] and with a 52% (complete) and 19% (partial) regression rate of the same lesions in the Austrian series by Zitt et al. [ 24].
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The rate of spontaneous partial regression among patients with HCC is 0.406% compared with the control arm of a randomized clinical trial.
However, independent of body mass, rewarming rate increased with decreasing initial Tb (effect of minimal Tb during the preceding bout of torpor on logarithmic rate of rewarming: standardized partial regression coefficient −0.24, F 1,783) = 53.1, p<0.001).
To some degree, this could be explained by decreasing body mass of winter fasting marmots (effect on logarithmic rate of rewarming: standardized partial regression coefficient −0.31, F 1,783) = 43.3, p<0.001; body mass assumed to decrease linearly from immergence to emergence mass).
β partial regression coefficient, SE standard error, EFV efavirenz, ATV/r atazanavir/ritonavir, eGFR estimated glomerular filtration rate, CTx C-terminal cross-laps, OPG osteoprotegerin.
β = standard partial regression coefficient, IOP = intraocular pressure, cpRNFLT = circumpapillary retinal nerve fiber layer thickness, MBR = mean blur rate.
No relationship was apparent in other partial regression plots.
Complete sustained regression, concomitant with massive differentiation and/or apoptosis, and partial regression are both observed.
For each regression analysis, the partial regression coefficient of the variable is given in bold and the P value of the partial regression coefficient in italics.
The standard partial regression coefficients of %SREM, %S2 and %S1 were somewhat higher than other parameters.
The significance of each partial regression coefficient was assessed using a two-sided Student-t test.
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