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Best responses were partial or stable diseases.
However, also patients with only partial or stable disease had long-term tumor remission.
A stratification was adopted considering centre and response achieved after first-line chemotherapy, in terms of progression during treatment (refractory patients), partial or stable disease, relapse within 12 months.
In all patients after the sixth cycle the response to treatment was assessed with an MRI and a PET scan to define three grades of response: complete, partial, or stable disease.
2, 3 Studies have suggested that 30%50%% of patients do not receive second-line treatment due to rapid disease progression, increased symptom burden, and decreasing performance status. 10 Hence the use of active maintenance therapy introduced immediately after first-line platinum doublet chemotherapy in patients with complete, partial, or stable disease response to treatment has been proposed.
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Objective response (complete plus partial response, OR), stable disease (SD) and progressive disease (PD) were 28.3, 49.4 and 22.2% respectively.
The objective response was defined as complete response or partial response, while disease control was defined as complete response, partial response or stable disease.
The primary endpoint was to assess clinical benefit response (complete or partial response, or stable disease for ≥ 16 weeks) following treatment with PF-04691502 or gedatolisib.
The rest presented partial remissions or stable disease courses.
At first assessment, patients achieved either a partial response or stable disease.
The overall response rate was 17%, and partial response or stable disease accounted for 66%.
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