It is, however, clear that this factor alone does not account for financial sustainability because three countries with weak programs have full government funding for AD syringes and safety boxes and two countries with high program strength have total or partial discontinuation of AD syringes.
Of more immediate concern may be that our findings also suggest that the partial discontinuation of plague surveillance following in the wake of the collapse of the USSR takes place at a time when current and near-future climate changes seem more likely to favor an increase than a decrease in plague activity.
For providers, partial compliance or discontinuation of medications represents the difficulty of maintaining treatment successes over time [ 9, 10].
The inclusion of only sustained remitters rules out the likelihood of registering reemergent depressive symptoms during relapses or partial relapses as discontinuation symptoms.
However, the maintenance of BMD after bisphosphonates discontinuation is partial at the femoral neck where a gradual decline in BMD occurred, although the values remained higher than at baseline.
These approaches included low-dose aspirin (ineffective [ 23]), warfarin (temporary partial relief), dipyridamole (discontinued due to epistaxis), antiplatelet therapy (ineffective) and discontinuation of birth control (with some positive results) [ 46].
This observation, coupled with a rapid partial rebound in weight after discontinuation of higher doses, suggests that diuresis may contribute to some weight loss.
In view of the previously reported association of bortezomib with thrombotic microangiopathy, the temporal association of the clinical picture with the initiation of carfilzomib, and the partial resolution of symptoms after discontinuation of the drug, we conclude that carfilzomib may have precipitated a case of clinically evident renal thrombotic microangiopathy in our patient.
Premature discontinuation, dosing lapses and partial non-adherence often occur [ 1– 3].
LTBI treatment regimens were assumed to have 90% treatment efficacy if completed [ 3, 22]; given variability in timing of drug discontinuation and efficacy of partial treatment, incomplete treatment was assumed to offer on average 25% of complete treatment protection [ 17, 21, 22].
In the scenario without sexual disinhibition after PrEP initiation, key parameters influencing infections prevented were effectiveness of PrEP (partial rank correlation coefficient (PRCC) = 0.94), PrEP discontinuation rate (PRCC = −0.94), level of coverage (PRCC = 0.92), and time to achieve target coverage (PRCC = −0.82).
