Sentence examples for partial abrogation from inspiring English sources

The same molecular mechanisms are involved in EDARADD mutations leading to complete or partial abrogation of NF-κB activation in both autosomal dominant and recessive mutations.

In sum, the model which emerges is one in which STAT3 signalling downstream from EGFR is required for persistent cell motility and invasion, and that partial abrogation of this pathway hinders this tumour progression.

That the α-TEA-mediated antitumor effect had a T cell-dependent component was demonstrated by the partial abrogation of tumor suppression when CD4+ and CD8+ T cells were depleted.

However, similar partial abrogation of sulfatide influence by actin polymerization inhibitor was detected in probes where PMNLs were challenged with sulfatides without bacteria, that is, when apoptosis did not result from phagocytosis.

In addition, the depletion of CD8+ or CD4+ lymphocytes showed partial abrogation of the antitumor activity of the combination therapy in vivo, which indicates the antitumor immunity of the combination therapy is dependent on both CD4+ helper and CD8+ cytotoxic T cells.

However, from therapeutic point of view, this crosstalk among several ROS generators appears to be advantageous since there is sound experimental evidence for the partial or even complete abrogation of oxidative stress (and of its deleterious consequences) by inhibiting a single source of ROS [ 12].

TRF2 Δ/Δ K5-Cre mice were born at submendelian ratios indicating partial embryonic lethality associated with TRF2 abrogation in stratified epithelia (Fig. 1A).

Our results showed that pretreatment of mice with a single injection of AcNPV 3 h or 3 days before FMDV challenge resulted in complete abrogation of mortality and complete or partial suppression of viremia, respectively.

Alternatively, binding site modification can also result in partial inhibition of an interaction (64), or even complete abrogation of an interaction (65).

The German period is also marked by the emancipation of the Jews that is, by the abrogation of discriminatory laws directed against them and by their partial or complete assimilation.

Interestingly, further in vitro expansion resulted in a partial loss of CD4+ cells expressing both CD62L and CD25 and abrogation of their regulatory activity in vivo.