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Exact(27)
In the case of metabolomics data, metabolites that are functionally related (e.g. part of the same pathway) may form a simple model.
We assumed that if the toxic species are part of the same pathway, the wt protein might titrate the toxic species formed by the m8 protein.
These data strongly suggest that PKA and p38alpha are part of the same pathway in regulating the transformation-dependent stimulation of NHE1 and that PKA is up-stream of p38.
Translating the general framework into the context of identifying surface membrane factors interacting with HIV-1 implies that proteins, which are related to known HIV receptors through functional similarity or interaction with the same ligand(s), tend to be part of the same pathway and often share the same biological function.
Our strategy is based on the assumption that proteins, which are related to known HIV receptors through functional similarity or direct interaction with the same ligands(s), tend to be part of the same pathway and often share the same biological function.
When individual integrations into the genome are used for each of the subunits, genes that are part of the same pathway may not be expressed to the same level or even in the same cell, even when expressed from identical promoters.
Similar(33)
Another important advantage lays in the fact that the perturbation of each pathway is quantified by an "aggregated" value, inferred from the statistical integration of dozens of genes taking part to the same pathway.
Strikingly, LESNICK-PD-UP indicated the same enrichments (contained parts of the same pathways) as MORAN-PD-UP.
Additionally, an important observation in our study was that the SNPs/genes that determine cluster formation in CD do not appear to group in specific pathways: eg TNFSF15 and IRGM, which explain cluster B (Figure 1B) are – to the best of our knowledge – not part of one and the same pathway.
For biological reasons first: since some genes are part of several pathways, the same pathway is not necessarily active in the two species either due to the species' specificities, or because the microarray data monitor different conditions in the two species.
The majority of the proteins analysed here are part of the same KEGG pathways: pathways in cancer (hsa05200), neurotrophin signaling pathway (hsa04722), and focal adhesion (hsa04510).
More suggestions(15)
part of the same tract
part of the same terminal
part of the same strategy
part of the same debate
part of the same nation
part of the same family
part of the same disease
part of the same whole
part of the savage pathway
part of the same story
part of the phenylpropanoid pathway
part of the same reform
part of the same picture
part of the endocytic pathway
part of the same package
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com