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The second important part of specificity, which will become even more important to us as we begin to detect caries lesions at a very early stage, is: Will the detected lesion progress if untreated?
As part of specificity validation of our antibodies, we learned through target knockdown analyses and mass spectrometry-based protein sequencing analysis that a MAb sold as anti-DCC actually recognised the unrelated protein HSPA9, or Mortalin.
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Type II receptors selectively bind their respective ligands to define part of the specificity of signal transduction [ 144].
SNAREs provide a large part of the specificity and energy needed for membrane fusion and, to do so, must be localized to their correct membranes.
The interpretation as a part of a specificity code is complicated by the observation that CadN is expressed in all presynaptic and postsynaptic neurons during distal medulla development; however, temporal regulation (Petrovic and Hummel, 2008) as well fine-tuning of expression levels (Schwabe et al., 2014) have been proposed as solutions.
Studies in this laboratory have shown that curcumin inhibits bladder and pancreatic cancer cell and tumor growth and that the anticancer activity is due, in part, to downregulation of specificity protein (Sp) transcription factors Sp1, Sp3, Sp4 and Sp-regulated genes [ 20, 21].
There are two parts of the specificity equation to think about.
During evolution, as new signaling pathways emerged from the duplication and divergence of pre-exiting parts, the issue of specificity must have been paramount.
Part of the assumed specificity could therefore be an artifact of the analysis.
These observations suggest that at least part of the subspecies specificity results from the differential loss of ancestral genes.
At least part of the functional specificity of SENPs appears to result in their subnuclear localization, with SENP3 being localized to the nucleolus and thereby de-SUMOylating nucleolar substrates, such as nucleophosmin [ 26], although recent results demonstrate that nucleolar SENPs, such as SENP3, can be released into the nucleoplasm following mild oxidative stress [ 23].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com