Interestingly, the study of tumor cell death biology has recently revealed that part of radiotherapy efficacy relies on its ability to trigger an immune response against tumor cells.
More recently, Colombet et al. [33] did not reach the same conclusions as us: however, they did not put any tension on the lateral sling, thus losing a big part of the efficacy of the technique itself.
The upper part of the efficacy curve of the triptans is generally flat, the so-called ceiling effect; and none of the oral triptans, even in high doses, are as effective as subcutaneous sumatriptan, In contrast, AEs increases with increasing dose without a ceiling effect.
These events were evaluated as part of the efficacy assessment and were not included in the assessment of safety.
For example, Gilliam and colleagues evaluated 24 individuals over 65 as part of an efficacy study of partial complex seizures; a total of 252 patients were evaluated.
For many drugs dosing is limited by side effects/toxicity, so the bell-shaped part of the efficacy curve is never reached.
87, 88 Mechanistically, infusion with live Lactococcus lactis led to a rapid and considerable innate immune response which may also form part of the efficacy.
Subjects who missed either, more than 2 consecutive days of dosing, or more than four total doses of their study agent per monthly interval were considered non-compliant and not included as part of the efficacy analyses.
Thus, incorporating intratumoral heterogeneity in a dynamic tumor model as part of preclinical efficacy determination could in turn provide better a better understanding of drug responses and would allow for improved prediction of novel treatment strategies.
