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The PART hypothesis artificially divides the progression (see Fig. 3).
The PART hypothesis raises questions that are currently impossible to resolve (Fig. 1).
We believe that the PART hypothesis does not add to the pathological description and may be confusing.
According to the PART hypothesis, 'age-related' medial temporal lobe NFTs – occurring in the absence of Aβ deposition differ from AD-related NFTs associated with Aβ deposition.
According to the PART hypothesis, the presence of Aβ deposits speaks for the presence of an AD-related process rather than a pure tauopathy.
According to the PART hypothesis, tau pathology in the ECH, when it is not accompanied by Aβ deposition, will not progress (or is less likely to progress).
Similar(52)
Thus emerges the four-part hypothesis [2]: 1. Model A(X) – Model A'(X) 0. Agent X type-A model at time t1 cannot be equal to Agent X type-A model at time t2. 2.
We agree that speculation is an important part of hypothesis making, but concluding that results of a study (which is also supported by all available evidence) are false-positive needs stronger evidence than speculations.
The fifth part provides hypothesis tests for model specifications.
The first part of Hypothesis 1 therefore cannot be confirmed.
Splitting the large SLC database into two parts yields one training part for hypothesis generation, and a second for validation purposes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com