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The prodrugs displayed increased solubility as well as other physiochemical properties favorable for parenteral use.
The final topic is the discovery and early development of a novel type of biodegradable polyesters for parenteral use.
With comparable toxicity and yield, no aggregation and cross-protection against other PorA subtypes, these OMV vaccines are potentially safe and effective for parenteral use in humans.
The prodrugs such as 16 had enough chemical stability and water solubility for parenteral use and were rapidly and quantitatively converted to the active substance in human plasma.
Finally, the consequences of these two factors on the design of lipid based carriers for oral, as well as parenteral use, for lipophilic drugs and lead selection of oral lipophilic drugs is described.
In this study the authors have examined the effects of tezosentan, a nonselective endothelin-A and endothelin-B receptor antagonist designed for parenteral use, on the cardiovascular and renal systems of healthy neonatal piglets.
Similar(17)
However, the approaches to parenteral anticoagulant use in the investigational treatment arms differed among the trials.
The potential immunogenicity of VHHs could compromise their parenteral therapeutic use, especially in treatments that require repeated injections.
Each of these sensitivity analyses concurs with the primary CMA, demonstrating significantly reduced costs associated with early parenteral nutrition use.
CVC-ABSIs were associated with parenteral nutrition use and CVC-ABSIs rate was higher in surgical rather than medical wards.
Slightly lower prevalence of enteral and higher prevalence of topical formulations was noted in the SES compared to the PPS with no difference in parenteral medicines use.
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