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Because oral vaccines induce more efficient mucosal immunity than parenteral immunization, an oral vaccine was developed with an improved yeast cell surface display technology to induce an immune response to IHNV.
Skin immunization has been shown to be superior to parenteral immunization for induction of both systemic and mucosal immune responses [56], [57], but the mechanisms whereby immune responses are induced in mucosal compartments distant from the initial skin site of vaccine administration are still unclear.
However, influenza protection generated after parenteral immunization could be improved by the induction of mucosal immune responses.
induces greater protection against Mtb challenge than parenteral immunization.
Samsun NN plants and used for parenteral immunization of mice.
Factors limiting an effective immune response include (a) envelope glycoprotein strain variation decreasing functional T-cell help, (b) alteration of the glycosylation patterns of gp120 by expression in different cell types, and (c) the native structure of gp120 itself, which may limit the elicitation of effective T-cell help during natural infection or during parenteral immunization in adjuvant.
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Parenteral immunizations with whole-cell, heat-killed vaccine preparations are very protective, but their use is limited due to severe side effects (pain, nausea, and fever), serovar-restricted protection, and short-term immunity [ 2].
To test whether next to intranasal administration also parenteral passive immunization with SHe immune serum could reduce HRSV replication, KLH or SHe-KLH immune serum or HRSV convalescent serum was injected intraperitoneally 16 h before HRSV challenge.
Recombinant virus-vectored TB vaccines represent the most promising vaccine platform for boosting the protective immunity mediated by parenteral BCG prime immunization.
Immunization with EF-Tu yielded high concentrations of antigen-specific IgG in the sera and BAL by both the parenteral and mucosal immunization regimens.
Parenteral but not mucosal immunization induced high serum immunoglobulin G (IgG) responses specific to P. vivax ookinetes isolated from P. vivax volunteer patients from Thailand.
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