Sentence examples for parental compound from inspiring English sources

The latter has advantages related to the economics of the process and it opens a way for total or partial modification of the parent structure with the desired functionality while still retaining the properties of the parental compound to a degree including the characteristics of the functional groups.

Following incubation in human serum, [18F]-9 indicates presence of parental compound up to 3h thus indicating its stability.

Due to its low membrane permeability, esterified 5-aminolevulinic acid derivatives less hydrophilic than the parental compound are under investigation.

We identified a derivative KKD-016 with antiviral and CD4 down-modulating capabilities similar to those of the parental compound CADA.

AEG3482, the parental compound, was identified in a screening effort designed to detect compounds that reduce apoptosis of neonatal sympathetic neurons after NGF withdrawal.

Des-ciclesonide was detected in 24 h culture HBEC supernatants using high-performance liquid chromatography, while no parental compound ciclesonide was present.

Among hetrocyclic compounds, quinoline compounds are important privileged structure in medicinal chemistry, are widely used as "parental" compounds to synthesize molecules with medical benefits, especially with anti-malarial and anti-microbial activities.

In this review article, we introduce a refinement of traditional drug repositioning and repurposing strategies involving the development of drugs that are based on the active metabolite(s) of parental compounds with demonstrated efficacy.

The multifactorial nature of Alzheimer's disease (AD) offers us a textbook example where parental compounds, mostly marketed, are modified with the aim of improving and/or conferring two or even more biological activities to contrast or less frequently revert the disease's symptoms.

In addition, variants of the parental compounds may regulate PXR activation in a tissue specific manner.

These agents showed improved properties over the parental compounds [ 50, 141].