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Studies demonstrate that the cyclic analogs have both similar in vivo activity to their parent molecules, and affinity for the Y2 and Y4 receptors.
Comparison of co-crystal structures of parent molecules and fluorinated counterparts revealed the importance of placing fluorine at the optimal position to achieve favorable interactions with protein side chains.
The reaction mechanism and kinetics of Co3O4/β-PbO2/Ti compositelectrodeselectro-catalytictic degradation bisphenol A mainly caused by the OH radical attacking parent molecules and the degradation followed pseudo-first-order kinetics.
We compared these parent molecules and identified a common basic scaffold, which is included in 32 of 40 clusters and in the search query.
Open image in new window Figure 7 Cell viability index (arbitrary unit) assessed in SACCH and SACC compared with parent molecules and control.
This can be expected since fragments are saturated with hydrogen atoms at positions of covalent bonds in their parent molecules and some of these hydrogens are able to form hydrogen bonds.
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These products are electrically more stable than the parent molecule and do not readily recombine.
The observed lag of several months between the signals of the parent molecule and those of the metabolites is probably due to greater sorption of the parent molecule than of its metabolites and/or to degradation kinetics.
There is some adsorption and mineralization of the parent molecule and its metabolites in the unsaturated zone, though less than in soils.
In brief, both reaction pathways are initiated by the ultrafast double ionization of the parent molecule and proceed through prompt formation of a roaming neutral H2 moiety from the methyl site.
The third component, comparative toxicity, was primarily designed to determine whether the metabolites had the same or similar toxicity profiles to their parent molecule, and also to one another.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com