In summary, we have identified a novel pool of putative parasitism-associated genes, a significant proportion of which, we hypothesize, will turn out to have parasitic functions after functional assays have been performed.
Compared to experimental interactions, we find that the addition of interologs enhances the enrichment of secreted proteins, confirming the particular role of the rich-club proteins for parasitic functions (Fig. 3c).
The high frequency of the dysfunctional CHIT1 genotypes is consistent with a founder effect and does not corroborate previous suggestions of a persisting anti-parasitic function of this gene.
Another line of evidence shows that IRG proteins accumulate on the T. gondii vacuole in a cooperative manner to regulate anti-parasitic Irga6 function [36].
Even in the absence of drastic infrastructure improvements, children in clean households fared better in measures of parasitic infection, gut function, and growth compared with children in contaminated households.
Therefore, we would expect the effect of interventions deployed to the general population to have smaller average improvements on parasitic infection, gut function, and growth than the improvements that we observed in this study, because most intervention households would experience less extreme environmental changes.
Figure 9b shows the averaged reflection and averaged parasitic loss as a function of H.
Given the functional conservation between dauer recovery and hookworm infection, there is considerable interest in the transcriptional outputs of DAF-16 in hookworm and their function in parasitic development.
The classic view of repetitive mobile genetic elements as parasitic DNA without beneficial function to the host is challenged in many ways.
TEs are repetitive mobile genetic elements that were originally considered to be parasitic DNA without any function, popularly termed "junk DNA".
