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Parastrongyloides trichosuri, an intestinal rhabdiasoid nematode parasite specific to possums, is being evaluated as a self-disseminating delivery system for engineered fertility control vaccines.
Trypanosome alternative oxidase is a parasite specific enzyme whose inhibition by the natural product ascofuranone (AF) has been shown to be curative in murine models.
AceCS from Leishmania donovani (LdAceCS) is significantly different from human host to be explored as a potential drug candidate to develop parasite specific inhibitors.
Novel quinazoline-type compounds were designed as inhibitors of the parasite specific enzyme trypanothione reductase (TR), and their biological activities were evaluated.
Researchers in the field of trypanosomatids would also benefit from a parasite specific lipid database, such as LIPID MAPS for mammalian cells, which is missing.
Besides, levels of total, brain or parasite specific IgG do not correlate with brain autoreactivity profiles.
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There is evidence that the immune system has a role in generating this host-parasite specific response.
However, the design of parasite-specific drugs that inhibit parasitic CYP51 without severe side effects remains challenging.
These critical biogenesis pathways present untapped opportunities to discover new parasite-specific drug targets.
Xu, H. et al. The mechanism and significance of deletion of parasite-specific CD4+ T cells in malaria infection.
In addition, various processes involved in regulation of parasite-specific genes and gene families are examined.
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