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RON4 and RON5 were not properly expressed (Supplementary Fig. 1d) and localized within parasite cells in absence of RON2.
The parasite cells were cultured in the presence and absence of CQ by in vitro method.
The compounds enter parasite cells rapidly and appear first in the kinetoplast that contains the mitochondrial DNA of the parasite.
Changes in actin, tubulin and myosin expression were confirmed by flow cytometry of parasite cells and immunofluorescence.
We wished to determine whether the relatively modest activity of trifluralin was the consequence of poor uptake into parasite cells.
Parasite cells expressing the ER-like protein were located by confocal microscopy in the subtegumental tissue exclusively.
Similar(7)
Early malaria genetic barcodes relied on DNA markers found in the parasite cell's nucleus.
The triazine molecules designed and synthesized showed low micro-molar activity against malarial parasite cell lines.
Initially, a 'distant' attachment is mediated by proteins secreted from the micronemes (MICs) and targeted to the parasite cell surface where they engage host cell receptors1.
The identities of proteins presented at the parasite cell surface that contribute to the MJ, however, remain a matter of debates7,8,9.
In a recent scientific paper, they described how they used many of the advanced techniques of bioengineering to analyze the parasite cell by cell, stage by stage, searching for some common weak spot to attack.
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