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The PARAMOUNT trial targeted this pathway from a different point of view and tested in patients with HFpEF LCZ696, a first-in-class ARNI that is a complex molecule from the combination of the neprilysin inhibitor prodrug AHU377 and the ARB valsartan.
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The JMEN, SATURN, and PARAMOUNT trials are examples of studies that used tumor response to preselect a subgroup of patients, but only after they completed all chemotherapy, and only to investigate maintenance treatment, pemetrexed or erlotinib [ 2, 5, 6].
"Do you really believe Ms. Thomas was paramount to the trial?" Balogh asked.
The implementation of strategies to monitor and enhance treatment fidelity is of paramount importance in trials of complex interventions.
Using a more rigorous design, i.e., a randomized trial, is paramount to reduce risk of bias and be able to draw stronger conclusions.
One reason is that safety considerations and execution of pre-clinical and clinical trials are paramount for vaccines because this medication usually is administered to healthy recipients.
An appropriate risk-stratified selection for adjuvant treatment trials is paramount, considering the high cost and toxic side effects of chemotherapeutic drugs.
Therefore, establishing accepted markers of effective aGVHD treatment which also serve as surrogates measures of long-term transplant survival is of paramount significance for aGVHD trials.
Attention to pancreas cancer staging, radiation techniques, and clinical trial design are paramount to interpreting the outcomes from adjuvant therapy.
The safety, rights and well-being of the trial participants are paramount.
Literature data suggested that MC treatment strategy is promising in the treatment of HNSCC, but a large-scale randomized trial should be paramount to test the optimal regimen to be used.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com