Sentence examples for paramount pathway from inspiring English sources

While both outcomes are important, the former would implicate GHR-based signaling as the paramount pathway controlling the effects of CR on aging and lifespan in mice and thus potentially one of the pathways that may be exploited to induce CR-like effects in humans.

Thus, it was of interest to unveil how PPARβ/δ controlled this paramount signaling pathway.

The presence of negative and positive feedback loops in biomolecular pathways is of paramount importance for pathway functionality and regulation.

Glucose absorption by a nectarivorous bird: the passive pathway is paramount.

The PARAMOUNT trial targeted this pathway from a different point of view and tested in patients with HFpEF LCZ696, a first-in-class ARNI that is a complex molecule from the combination of the neprilysin inhibitor prodrug AHU377 and the ARB valsartan.

However, an understanding of the nature of these pathways is paramount before designing therapeutic strategies.

In order to place iliosacral screws safely, a thorough understanding of the possible osseous fixation pathways is paramount [5, 6].

The discovery and characterization of new drugs targeting key enzymes involved in essential mycobacterial biosynthetic pathways is paramount but without the introduction of novel lead compounds, such as platensimycin antitubercular therapy will not proceed fast enough to cope with the increasing resistance observed today.

The role of therapeutic drug agents targeting aberrant molecular pathways is paramount as well.

Understanding the mechanism through which H2O2 modulates signalling pathways is paramount to unearthing the signalling role of Noxs.

Consequently, the identification of the cancer stem cell and an understanding of the mechanisms driving its self-renewal and differentiation pathways are paramount to targeting and to hopefully eradicating the tumour.