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The individual tumour microenvironment is a paramount determinant in the outcome of non-surgical treatments (Vaupel et al, 1989; Höckel and Vaupel, 2001).
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To develop novel prognostic adjuncts and therapeutic interventions, it is of paramount importance to elucidate the molecular determinants correlated with tumour aggressiveness and metastatic spread in myxofibrosarcoma progression.
A better knowledge of the determinants of renal function is of paramount importance considering the high and increasing burden of chronic kidney disease worldwide.
The growth hormone/insulin like growth factor-1 (GH/IGF-1) axis is of paramount importance in growth and development and is also a lifespan determinant in animal models [ 1– 5].
Therefore, the continued search for determinants and predictors of occurrence and prognosis of CVD is of paramount importance.
Paramount Building.
Security is paramount.
Self-interest is paramount.
Fit is paramount.
Safety should be paramount.
Two issues are paramount.
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