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Investigations aimed at discovering clinical and pathologic parameters with prognostic and/or therapeutic significance in these neoplasms are considered an important field of study in this species [ 28], also in light of the potential usefulness of the animal model for the study of human breast cancer.
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In this context, there is a need for a clearly relevant parameter with prognostic value for patients in the initial phase of TBI.
Our results showed that the poor prognostic value of the overexpression of these markers was highest when all the four biomarkers and two histological parameters with individual prognostic significance were taken into consideration together.
We could not detect imbalance in entry parameters with relevant prognostic significance for survival or disease progression which could account for the lack of treatment efficacy.
Parameters with independent prognostic significance for PFS were poor performance status (PS 2-3 vs 0-1, HR for disease progression 18.2, p = 0.0004) and occurrence of metastasectomy (HR for disease progression 0.04, p = 0.0015).
The complex molecular mechanism by which beta-catenin relates to other parameters with potential prognostic or diagnostic value like viruses (e.g., HPV) and various oncogenes and tumor suppressor genes (p16, EGFR, p53, etc).
SR were identified as independent parameters with potential prognostic relevance on survival While aR did not significantly influence survival, SR showed a positive and independent impact on survival (OR = 0.589; 95%-CI: 0.354 - 0.979).
The association between P- and E-cadherin expression and four clinicopathological parameters with known prognostic value in feline mammary tumours, namely ulceration [ 46, 47], necrosis [ 47], infiltrative growth [ 44], and tumour largest diameter [ 47- 49], was also addressed in this study.
When all parameters with significant prognostic impact in univariate analysis (i.e. preoperative PSA, pT stage, GS, and the extent of Tiam1 overexpression) were included in the model, only pT stage (P=0.028, hazard ratio=4.61), GS (P=0.019, hazard ratio=1.80), and the extent of Tiam1 overexpression (P=0.04, hazard ratio=3.75) reached statistical significance in predicting decreased DFS (Table 3).
The intra-abdominal pressure (IAP) is an important clinical parameter with major prognostic impact [1, 2].
The intra-abdominal pressure (IAP) is an important clinical parameter with major prognostic impact [ 1, 2].
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