Macular parameters show the greatest variability among different OCT devices and algorithms [ 14]; discrepancies have also been noted across different versions of OCT [ 15, 24].
The two most variable parameters are shown in Figure 2b, all other parameters showed less variability across the conditions (data not shown).
Both of these parameters showed marked variability in this study and, using the AUIC as a predictor of adequacy of therapy, 63% of patients had insufficient levels.
However, some of these parameters show a high interobserver variability (e.g., tumour grade or Ki-67 staining) and even predictive accuracy of the combination of such prognostic factors to prognostic scores is far from perfect (Pichler et al, 2011).
Also, MR parameters showed no significant variability before start of VLCD, as shown in Supplementary Table 2.
Soil parameters showed a relatively high variability, particularly of CaCO3-C and EC (86% and 163%, respectively).
Again, heart rate and all heart rate variability parameters showed a main effect of block (see Table 5, VC: p = 0.015, RMSSD: p = 0.019, VLF power: p = 0.017, LF power: p = 0.023, HF power: p = 0.006, LF/HF: p = 0.033, HR: p < 0.001), indicating that the mental stress paradigm did indeed significantly affect these parameters.
Our second, somewhat confirmatory, finding was the significant positive correlation between QTVI and left ventricular ejection fraction in patients with CHF, 10 whereas, in healthy control subjects, all repolarization variability parameters showed a significant relation only with age.
Plasma PK parameters showed low to moderate variability with a generally dose-dependent increase in exposure over the dose range of 100 225 mg based on Cmax and AUC(0 10).
The within-subject variability of the measured parameters showed considerable variations but it was not affected by the increase of the PIP.
Major findings were: Intra-subject variability in indices characterizing the dynamic interactions between cardiovascular parameters shows that coupling between physiological rhythms is time-varying and intermittent.
