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In dogs presenting different histopathological patterns of glomerulonephritis, parameters of proliferation and apoptosis were studied.
Further in the present study, no difference was seen between immunoglobulin and C3b deposit intensity in glomeruli between infected and non-infected dogs thus T cells, adhesion molecules and parameters of proliferation and apoptosis were analysed in dogs with naturally acquired VL from an endemic area.
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After a specific substrate reaction with tetramethylbenzidine, spectrophotometrical measurement of absorbance indicates the extent of newly synthesised DNA as a parameter of proliferation.
As an additional parameter of proliferation, we determined the expression levels of the cell cycle regulator gene cyclin B1, using a CYCB1 GUS transgenic plant line.
Tumor growth and the related parameters of cell proliferation were measured.
Based on the mathematical formulation, we developed an algorithmically and conceptually simple way for estimation of kinetic parameters of lymphocyte proliferation and death.
Placebo treatment did not significantly alter any of these parameters of cell proliferation.
Likewise, in addition to the conventional histopathological parameters, the assessment of proliferation is one of the major factors for the treatment decisions in breast cancer patients [ 4].
While a trend towards more frequent PR-positivity for ILC than IDC tumors was noted in the older AUS cohort (84.8 vs. 76.6%; p <0.08), no such trend was demonstrable for HK-ILC over HK-IDC (75.4 vs. 72.7%, p >0.5).> An analysis of tumor parameters in terms of proliferation rate, as defined by Ki67 high (≥10%) and low (≤5%) cutoffs, is shown for ILC and IDC in Tables 3 and 4 respectively.
The other half was fixed in 10% neutral-buffered formalin and used for immunohistochemical analysis of the Ki67, a parameter of cell proliferation.
The other commonly studied parameter of cell proliferation is mitotic activity.
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