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As a consequence of the improved prognosis and risk-adapted treatment, the prognostic significance of a number of parameters at presentation has decreased.
This paper continues with a description of the on/off model, discussion of its parameters, and presentation of the simulation results.
To test this hypothesis we considered that the adverse immunotoxic effects of PRN exposure on cell-mediated immunity might be observed in one or more of three parameters: a) presentation of peptide antigen to CTLs by antigen-presenting cells (APCs), b) proliferation and differentiation of CTLs, and/or c) functional lytic response of activated CTL effectors.
Evaluating the value of AGBA parameters at presentation as a diagnostic test, we found that neither the presence of respiratory or metabolic acidosis or alkalosis nor individual or combined absolute values of ABGA parameters were able to reliably identify specific disorders responsible for dyspnea or to distinguish patients with pulmonary disorders from other causes of dyspnea (Table 1).
Clinical parameters at presentation, kind of therapy and clinical outcome were recorded.
Values of ABGA parameters at presentation varied widely in all underlying disorders.
For simplicity of presentation, the parameters in the distribution of g and e are omitted.
Various physiological parameters estimated at the time of presentation were analyzed to find predictors of mortality.
Clinical parameters documented at the time of presentation to the outpatient department included tender and swollen joint count, and concentrations of C-reactive protein (CRP) and of RF IgM.
We abstracted all of these parameters from the first 24 hours of presentation.
Baseline hematological and biochemical parameters were recorded for the date of presentation, and blood and tissue culture results were documented.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com