Secondary aims are to understand whether vitamin D3 supplementation improves parameters of bone microarchitecture, balance, physical function and quality of life.
The bone architecture of F508del Cftrtm1Eur and wild-type (WT) littermate mice was evaluated by bone densitometry, microcomputed tomography, and analysis of the dynamic parameters of bone formation.
This investigation of microstructure in the human proximal femur probes the relationship between the parameters of the FRAX index of fracture risk and the parameters of bone microstructure.
PFTBA supplementation significantly increased structural parameters of bone in radial bone defects and triggered a significant 1.4-fold increase in bone volume in the spinal fusion model.
However, bone strength and fracture risk are also influenced by parameters of bone quality such as micro-architecture and tissue properties.
To date, no reliable method is available to determine the parameters of bone density based on the routine spinal computed tomography (CT) in the emergency setup.
For this reason there has been increasing interest in studying architectural parameters of bone, beyond bone density, which may affect bone strength.
Histomorphometric parameters of bone structure, architecture and connectivity were measured on sections from the ultradistal part of the femoral neck, divided in 4 quadrants.
High resolution pQCT (HRpQCT) allows assessment of volumetric BMD (vBMD), and size and microarchitecture parameters of bone, while 1H magnetic resonance spectroscopy (1H MRS) allows MAT evaluation.
The trabecular architecture was described using parameters of bone morphology comprising the first 5 mm (examined in 1 mm steps) below the SBP.
Overall, systemic lentiviral-mediated gene therapy results in a measurable improvement in parameters of bone mass and architecture as well as biochemical and enzymatic correction.
