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It has been reported that CES1 mRNA abundance was positively correlated with clinical parameters of adiposity, which also suggests a role of CES1 in the development of obesity-associated phenotypes (Nagashima et al., 2011; Marrades et al., 2010).
We have recently demonstrated that both types of FABP circulate in the human bloodstream (2, 3), with levels closely associated with parameters of adiposity, insulin resistance, the metabolic syndrome, and carotid atherosclerosis (2– 4).
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Stefan et al. (13) recently reported that in the model of the metabolically fit but obese individuals, preserved insulin sensitivity was more strongly associated with lower IHF content than with other parameters of body adiposity, including intramyocellular lipid content.
However, treatment of obese animals by specific PPAR delta agonists results in normalization of metabolic parameters and reduction of adiposity.
Potential correlations with demographic, anthropometric and clinical parameters, with markers of adiposity and with breast tumor characteristics were also investigated.
Data from 6 samples of 5- to 6-year-old children followed up in 1957 and 2012 were used for the comparison of morphological parameters and markers of adiposity (Table 1).
The results of this analysis demonstrated that all the correlations remained significant regardless of the parameter of body adiposity.
In keeping with the experimental findings, several clinical investigations showed that serum A-FABP was associated with the parameters of insulin resistance, adiposity, and hyperglycemia [11].
To elucidate the influence of EpF, we adjusted for all of the confounding factors and parameters of inflammation and adiposity simultaneously in model 6.
The only study addressing this with clamp-derived glucose homeostasis parameters and direct measures of adiposity concluded that 25(OH D deficiency in PCOS does not directly affect the development of insulin resistance but rather results from the presence of obesity, independent of PCOS (29).
Based on testing five non-linked SNPs and three independent parameters, i.e., measures of adiposity, measures of insulin secretion, and measures of insulin action, we performed 15 independent statistical tests in the OGTT group.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com