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By 48 h, neither the C. albicans pixels nor the amount of host infiltrate was as strongly correlated with lesion density or viable burden as at 24 h (Table 2), suggesting that the different 48 h parameters may reflect the outcomes of intra-lesional phagocytic processes.
For example, relatively high values of any of the 3 biochemical parameters may reflect the general health of a patient, which may not change as a result of treatment geared to normalizing a single abnormality.
Specifically, our data suggest that network parameters may reflect unique characteristics of transgender patients, whereas local physiological aspects have been shown to represent the transition from the biological sex to the actual gender identity.
Because the IVIM model fits the signal decay with a bi-exponential decay, as opposed to the mono-exponential decay described by the ADC model, the IVIM parameters may reflect water diffusion and blood perfusion more accurately [ 8].
In fact, by evaluating a possible correlation of perfusion parameters with histological findings, particularly with microvessel density (MVD), a prognostic marker of RCC, we found a significant correlation between BF and BV and MVD (P < 0.01), suggesting that these CTp parameters may reflect blood vessels and then neoangiogenesis of RCCs, as also suggested by previous studies [ 10, 24].
In regard to critical patients, these parameters may reflect fluid accumulation, but only in extra-vascular spaces, as usually observed in burn and septic shock patients with capillary leakage syndrome caused by a systemic inflammatory response or a fluid shift caused by hypoalbuminemia [ 19, 20].
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Changes in this parameter may reflect multiple functions and at the current stage no specific function can be assigned to the insulin effect.
In particular, change in any structural damage parameter may reflect the possibility that there are more severe structural changes at baseline in the TNFα inhibitor group due to confounding by indication.
Changes in V e might also be expected, as this parameter may reflect changes in the extracellular extravascular space due to the shrinkage of neo-angiogenic vessels after antiangiogenic therapy.
Our analysis also uncovered previously undescribed interactions between parameters that may reflect true biological interactions, and at the same time found very low sensitivities in parameters that were previously thought to be most informative in explaining the overall architecture of distinct enhancers.
Further research into parameters that may reflect changes in physiological reserves may strengthen these scores for such patients.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com