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There are five parameters in the final model including the concentration of active sites, Cσ, one reaction rate constant: kDCB and three equilibrium constants: K1,K2 and Ke.
The MLEs of the parameters in the final model are listed in Table 7.
Parameters in the final model were fitted to experimental data from different groups.
This suggests that the parameters in the final model were reasonably well determined and the model was stable.
These herds departed from the overall average line predicted by the fixed parameters in the final model.
However, a relatively high η-shrinkage (up to 43.5%) could be seen for certain parameters in the final model because of the sparse data.
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Inclusion of a specific radiographic parameter in the final model required a specificity ⩾75%, a PPV ⩾50%, and a NPV⩾50%: the radiographic feature satisfying these three criteria was assigned a point value of 1 (Bristow et al, 2000).
In addition to ethnicity and diabetes duration the practice unit was a significant parameter in the final model of the multiple regression analyses and organisational matters like the staffing of practices and lack of effective cooperation between GPs and secondary care may contribute to poorer diabetes control in the ethnic minority groups.
With the exception of the age variables for the random effects ordered probit model for the urban case, which are significant well above the 90%% level, the retained parameters in the final models are significant at the 95%% level (with most of them being significant at least at the 99 % and 99.9 % levels).
Finally, the Heckman method is very sensitive to how the model is specified; in other words, omitting variables that are associated with either non-response or with the outcome of interest (in this case, health related quality of life measures) can lead to inaccurate findings and biased estimates of the parameters in the final models.
By stepwise backward selection only significant parameters remained in the final model.
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