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The frequency of exacerbations increases in parallel with the severity of COPD [ 7].
PCT, IL-2 and IL-8 levels increased in parallel with the severity of the clinical condition of the patient.
During OA, aggrecans are among the first matrix constituents to be affected, as they are progressively depleted from cartilage in parallel with the severity of the disease [ 23].
We demonstrated that in patients with sepsis, serum NGAL levels increase in parallel with the severity of sepsis, severity of illness and severity of inflammation and thus increased levels might not automatically reflect tubular damage.
In critically ill patients, in parallel with the severity of the injury, increases in proinflammatory cytokines, glucocorticoids, and oxidative stress reinforce the effect of catabolic hormones, and contribute to insulin resistance and muscle wasting [ 18, 19].
Measurements of retinal hemodynamics in response to stimuli have shown abnormal autoregulation of retinal blood flow in DR patients, with flow increasing in parallel with the severity of retinopathy (8).
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In the present study, we found that plasma OPN level, but not N-half OPN parallels with the severity of nephropathy and CAD in diabetes, suggesting that an increased plasma OPN level may be used as an indicator for screening diabetic vasculopathy.
Other indicators for the oxidative stress in diabetes the elevated levels of advanced glycation end products (AGE) that rise in parallel with the severity and complications of the disease [ 11, 12], as we can demonstrate this during the elevation of HbA1c in diabetes [ 13].
We conclude that PIIIP serum levels increased in parallel with the increasing severity of septic process, probably being a good indicator of tissue inflammation, damage, and fibrogenesis.
Healthy, fully coordinated animals show only normal step sequences (RI = 100%), but in arthritic rats that exhibited loss of paw placements of affected paws, the RI decreased in parallel with the increasing severity of arthritis.
In general, the severity of the multifocal axonal injury is parallel to the severity of the TBI.
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