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Prior work has shown that transcriptional downregulation of histone occurs in parallel with the inhibition of DNA synthesis by p53 [41].
Arsenite decreased the UVR-induced caspase-3/7 activity in parallel with the inhibition of apoptosis.
These experiments were performed in parallel with the inhibition of eEF1A2, which were also performed with two unrelated siRNA.
We found that this triterpene suppressed both constitutive and inducible STAT3 activation in human HCC cells in parallel with the inhibition of JAK1, JAK2 and Src activation.
Interestingly, Sesns induced by ROS are inhibitors of ROS accumulation, thus they can control ROS levels trough their intrinsic antioxidant activity in parallel with the inhibition of TORC1 and stimulation of autophagy (mitophagy).
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Results show that punicic acid inhibited p38MAPK phosphorylation paralleling the inhibition of p47phox phosphorylation on Ser345 with almost no detectable Phospho-Ser345 and phospho-P38MAPK at 20 µM punicic acid (Figure 2C and 2D).
In this study we used P-gp deficient host cells [3] in parallel with pharmacological inhibition of P-gp, thereby enabling more selective insights into the specific role of T. gondii P-gp.
In A549 human lung cancer cells, ethaselen significantly suppresses cell viability in parallel with direct inhibition of TrxR1 activity.
However, staurosporine attenuates the activation of Akt in cultured HEK293 cells stimulated with insulin in parallel with an inhibition of Thr308 phosphorylation, but has no effect on Ser473 phosphorylation (Hill et al, 2001).
In this model of hyperglycemia, we found that these changes in diabetic WT mice were associated with activation of PKC in parallel with inhibition of Akt/PKB phosphorylation.
Further analysis found that, in parallel with inhibition of stimulus-mediated p38 activation, Rit silencing inhibited stress-induced Akt activation, mirroring the results from ROS stimulated Rit−/− MEFs.
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