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In eukaryotes, the evolution of DNA methylases appears to have proceeded in parallel to the elaboration of histone-modifying enzymes and the RNAi system, with functions related to counter-viral and counter-transposon defense, and regulation of DNA repair and differential gene expression being their primary ancestral functions.
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The discovery of REM sleep led to the elaboration of a whole taxonomy of sleep.
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This quantitative increase is attributable in part to the elaboration of the regions of the neocortex concerned with tactile and visual sensitivity and in part to the elaboration of the intrinsic pathways connecting one part of the brain with another.
All authors contributed to the elaboration of the protocol.
BB contributed to the elaboration of the paper.
All the authors contributed to the elaboration of this manuscript.
TSP contributed to literature review and to the elaboration of the manuscript.
UNICEF made a great contribution to the elaboration of this law.
EA participated to the elaboration of the study and experiment design.
AT, YD, and LP participated to the elaboration of the study design.
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