The increased H3K4me2 enrichment associated with the ICP4 promoter corresponds to decreased enrichment of the H3K4me2 of the LAT 5'exon in a parallel time frame.
However, in previous studies in small ruminants (sheep [ 4, 13, 14, 49, 52] and goats [ 5, 7, 21]), most animals were euthanized at 6 months, paralleling the time frame of experiments in laboratory animals.
She has a weakness for pairing parallel events in her two time frames, so that fiascos, hospitalizations and moments of dramatic ripening precisely coincide.
There are three time frames.
Measurements outside these time frames were excluded.
At this point, Mr. Carey resorts to what comes easily to him but is so often a cheap trick for other writers: he adds a parallel narrative in a different time frame.
Also, in mouse Leydig cells, thyroid hormone has been reported to increase the levels of StAR protein and StAR mRNA, and their increased expression occurs in a time frame that parallels the acute production of steroids (28, 35, 49).
But by introducing a parallel plot, set in the same time frame and also having to do with a missing person, she loads the narrative with so much weight that it falls right into the pit she's dug for it.
Unfortunately, the rates of increase in BUN and serum creatinine do not parallel the fall in GFR in a time frame that is clinically useful.
Despite these caveats, our work here demonstrates that this WGS approach can provide highly discriminatory information within a clinically relevant time frame, but requires a parallel epidemiological investigation to rule in or rule out potential environmental sources.
