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There is a parallel hypothesis to this in terms of early initiation of medical therapy in PD and its potential for beneficial plastic changes in basal ganglia circuitry.
A parallel hypothesis could be that the genetic aetiology of human spina bifida will prove less complex than anencephaly, in which many more genes are potentially implicated from mouse models.
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Parallel hypothesis-led and hypothesis-free approaches were adopted to identify core genes that underpin insect epithelial function.
We adopted parallel hypothesis-led and hypothesis-free approaches, to maximise the unbiased discovery both of genes that underly functions already described in the physiological literature, and to uncover new co-enriched genes that might provide novel insights into epithelial function.
The results presented here indicate that the age-specific incidence data for most human carcinomas is consistent with the parallel route hypothesis as expressed in Equations 3 and 4. The parallel routes hypothesis, then, implies (through the age specific-incidence data) that only a subset of the population is susceptible to developing each carcinoma.
The parallel route hypothesis is consistent with the colon carcinoma age-specific incidence data, while the multi-stage hypothesis is not.
For this reason, the initial "two-hit" theory explaining the progression from NAFLD to NASH has been evolved into the "multiple parallel hits" hypothesis (Jou et al., 2008; Buzzetti et al., 2016).
This parallel route hypothesis has not been tested with age-specific incidence data.
This formulation has three parameters just like the formulation of the parallel route hypothesis.
The parallel routes hypothesis was consistent with the age-specific incidence date for lung and colon carcinomas for all 32 years.
See Figure 2. Detailed graphs of the data, along with the parallel routes hypothesis, are shown for 2003 in Figure 3.
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