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For parallel bound molecules, volume exclusion with the surface would result in an average height of about 15 nm above actin.
At the same time, the off-axis component of the transient state is much smaller compared to those trajectories when the transient state remains visible in both channels, which is most consistent with a parallel bound molecule lifting the detached head ∼40 nm up.
At the same time, the off-axis component of the transient state was much smaller compared to those trajectories when the transient state remained visible in both channels, which is most consistent with a parallel bound molecule lifting the detached head up by ∼40 nm.
Similar(57)
Is There Parallel Binding of Distributed Objects?
Crystallographic analyses of the paired-end complex (PEC) formed from precleaved transposon ends and the transposase of the eukaryotic element Mos1 reveals two parallel ends bound to a dimeric enzyme.
Extended circulation times can exploit the EPR effect to enhance transport of AuNPs to the tumor site, while in parallel, the particles' bound targeting molecules increase the rate of endocytotic uptake [22, 25].
If RNA molecules bound parallel to the long fibril axis, as has been proposed for heparin, then a single nucleic acid molecule, depending on polymer length, could associate with tens or hundreds of layers of Tau proteins.
In that case we would require most molecules to be bound parallel to the surface and then expect the average position of the detached head to be displaced ∼56 nm along and not more than 20 nm perpendicular to the filament.
We agree with the referees that it is in principle possible that molecules bound parallel to the glass surface and under the assumption of rotational diffusion would exhibit an average position of the detached head to the side of the actin filament (Author response image 1).
For an α-helical peptide bound parallel to the surface of the micelle, this results in a wave with a 3.6 residue periodicity.[ 34b] The tilt and azimuth angles of the peptide are obtained by least-squares fitting of experimental PREs to this wave-like function.
Now that the precedent has been set, the parallel slalom is almost bound to be a permanent part of the alpine World Cup.
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